Psychiatrie und Psychotherapie


       Klinikum rechts der Isar

          Ismaninger Straße 22
          81675 München
          81664 München

          Tel:  +49 (89) 4140 - 0
          Fax: +49 (89) 4140 - 4837

Evidence-based psychiatry

Section Evidence-Based Medicine in Psychiatry

Head: Prof. Dr. med. Dr. h.c. Stefan Leucht

Tel.: 089 4140-4249



The concept of evidence-based medicine is now widely accepted and the basis of treatment guidelines. Journals such as "The Lancet" require that the need for each new study be justified by a meta-analysis of the current state of knowledge. Due to growing publication numbers, the need for these procedures will continue to increase, with systematic reviews currently being published the most in the neurosciences.

At the same time, the preparation of treatment guidelines (guidelines) has also become very complex. These developments make it necessary to continuously improve the methodology of clinical trials, systematic reviews, and guidelines.


The Section "Evidence-Based Medicine in Psychiatry" is dedicated to the following tasks in particular:

1. Production of high-quality state-of-the-art systematic reviews, including:

2. improving the methodology of systematic reviews, e.g.

  • Further development of methods for estimating missing values
  • Further development of statistics of network meta-analyses
  • Improving methods for detecting publication bias
  • Automated data extraction and result generation

3. Conducting clinical trials in psychiatry

4. Improve clinical trial methodology, e.g.

  • Develop patient-relevant outcomes for psychiatry
  • Standardize outcome collection of clinical trials
  • Evaluate statistical methods of clinical trial evaluation

5. Support public institutions or medical societies in the development of treatment guidelines.


The Section maintains countless, active, national and international collaborations such as with the German Cochrane Center, the Cochrane Schizophrenia Group, Center for Evidence Based Mental Health Oxford, UK, King's College London, University of Aarhus, Denmark, Hoofstra University, New York, University of Illinois at Chicago, University of Ioannina, Greece, University of Kyoto, Japan and many others.